Article

Role of surface negative charges in agonist binding to the ‘unliganded’ open state of the neuromuscular acetylcholine receptor

2024-12-24

Abstract excerpt

Acetylcholine receptors (AChRs) expressed at the nerve muscle junction (NMJ) synapses are hetero-pentameric ligand-gated ion channels with two neurotransmitter binding sites (TBS) at α-δ and α-ε (adult)/γ (fetal) subunit interfaces. They are typical allosteric proteins which reside in at least two stable conformations: resting ( C losed) and active ( O pen) states. Mechanism of agonist (A) binding to the C state...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c48e1235-8f8f-5a57-acd5-11e7d85c28c2
DOI: 10.1101/2024.12.23.630096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of surface negative charges in agonist binding to the ‘unliganded’ open state of the neuromuscular acetylcholine receptorDOI 10.1101/2024.12.23.630096Read

Structural basis of agonist selectivity for different nAChR subtypes: insights from crystal structures, mutation experiments and molecular simulations.Semantic proximity Read

Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors.Semantic proximity Read

Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations.Semantic proximity Read

Acetylcholine receptor channels activated by a single agonist molecule.Semantic proximity Read

The effect of unliganded gating on agonist response in nicotinic receptors.Semantic proximity Read

Nicotinic receptor transduction zone: invariant arginine couples to multiple electron-rich residues.Semantic proximity Read

Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptorSemantic proximity Read

Agonist efficiency links binding and gating in a nicotinic receptor.Semantic proximity Read

Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes.Semantic proximity Read

Principal pathway coupling agonist binding to channel gating in nicotinic receptors.Semantic proximity Read

Unliganded gating of acetylcholine receptor channels.Semantic proximity Read

Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating.Semantic proximity Read