Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain.

Abstract excerpt

Acetylcholine receptor channel gating is a brownian conformational cascade in which nanometer-sized domains ("Phi blocks") move in staggering sequence to link an affinity change at the transmitter binding sites with a conductance change in the pore. In the alpha-subunit, the first Phi-block to move during channel opening is comprised of residues near the transmitter binding site and the second is comprised of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acetylcholine
• Share to Electrophysiology
• Share to Extracellular Space