Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylcholine receptor channels activated by a single agonist molecule.

Biophysical journal - 19 May 2010

Jha Archana, Auerbach Anthony

Abstract excerpt

The neuromuscular acetylcholine receptor (AChR) is an allosteric protein that alternatively adopts inactive versus active conformations (R<-->R). The R shape has a higher agonist affinity and ionic conductance than R. To understand how agonists trigger this gating isomerization, we examined single-channel currents from adult mouse muscle AChRs that isomerize normally without agonists but have only a single site...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Cell Line
Share to Choline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Ion Channels

Share to Ligands

Share to Receptors, Cholinergic

Source

Open in PubMed Open full text

Identifiers

PMID: 20441747
DOI: 10.1016/j.bpj.2010.01.025
PMCID: PMC2862204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetylcholine receptor channels activated by a single agonist molecule.PMID 20441747Read ↗

Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations.Semantic proximity Read ↗

Unliganded gating of acetylcholine receptor channels.Semantic proximity Read ↗

Design and control of acetylcholine receptor conformational change.Semantic proximity Read ↗

A speed limit for conformational change of an allosteric membrane protein.Semantic proximity Read ↗

Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors.Semantic proximity Read ↗

Role of surface negative charges in agonist binding to the ‘unliganded’ open state of the neuromuscular acetylcholine receptorSemantic proximity Read ↗

The effect of unliganded gating on agonist response in nicotinic receptors.Semantic proximity Read ↗

Agonist efficiency links binding and gating in a nicotinic receptor.Semantic proximity Read ↗

Structural basis of agonist selectivity for different nAChR subtypes: insights from crystal structures, mutation experiments and molecular simulations.Semantic proximity Read ↗

Mapping heat exchange in an allosteric protein.Semantic proximity Read ↗

Modal affinities of endplate acetylcholine receptors caused by loop C mutations.Semantic proximity Read ↗

Agonist- and competitive antagonist-induced movement of loop 5 on the alpha subunit of the neuronal alpha4beta4 nicotinic acetylcholine receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.