Article
Design and control of acetylcholine receptor conformational change.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2011
Jadey Snehal V, Purohit Prasad, Bruhova Iva, Gregg Timothy M, Auerbach Anthony
Abstract excerpt
Allosteric proteins use energy derived from ligand binding to promote a global change in conformation. The "gating" equilibrium constant of acetylcholine receptor-channels (AChRs) is influenced by ligands, mutations, and membrane voltage. We engineered AChRs to have specific values of this constant by combining these perturbations, and then calculated the corresponding values for a reference condition. AChRs were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.