Article
A speed limit for conformational change of an allosteric membrane protein.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005
Chakrapani Sudha, Auerbach Anthony
Abstract excerpt
Neuromuscular acetylcholine receptors are synaptic ion channels that open and close with rate constants of approximately equal to 48,000 s(-1) and approximately equal to 1,700 s(-1), respectively (in adult mouse, at 24 degrees C, -100 mV membrane potential). Perturbations of many different sites in the protein can change these rate constants, with those in the extracellular domain mainly affecting channel-opening...
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