Article
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.
Structure (London, England : 1993) - 1 Oct 2004
Zhou Tianjun, Raman Malavika, Gao Yan, Earnest Svetlana, Chen Zhu, Machius Mischa, Cobb Melanie H, Goldsmith Elizabeth J
Abstract excerpt
TAO2 is a mitogen-activated protein kinase kinase kinase (MAP3K) that doubly phosphorylates and activates the MAP kinase kinases (MAP2Ks) MEK3 and MEK6. The structure of the kinase domain of TAO2 (1-320) has been solved in its phosphorylated active conformation. The structure, together with structure-based mutagenic analysis, reveals that positively charged residues in the substrate binding groove mediate the...
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