Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.

Abstract excerpt

Kinases regulate key signaling processes that are increasingly implicated in development and disease. Kinase modulators have become important therapeutic tools and often target catalytic domains that are among the most structurally and functionally conserved regions of these enzymes. Such therapies lose efficacy as mutations conferring resistance arise. Because interactions between distinct and often distant...

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