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Article

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.

Cell cycle (Georgetown, Tex.) - 1 Apr 2004

Bayliss Richard, Sardon Teresa, Ebert Judith, Lindner Doris, Vernos Isabelle, Conti Elena

Abstract excerpt

The mitotic kinases Aurora-A and Aurora-B have similar amino-acid sequences but are differently localised and regulated during cell division. The basis for their interactions with different and specific regulators is unclear. Surprisingly, our recent structural studies indicate that TPX2 regulates Aurora-A activity by binding at a site that is conserved almost completely on Aurora-B. Here we investigate molecular...

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Source

Identifiers

PMID: 14752279

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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