Article
Kinases and pseudokinases: lessons from RAF.
Molecular and cellular biology - 1 May 2014
Shaw Andrey S, Kornev Alexandr P, Hu Jiancheng, Ahuja Lalima G, Taylor Susan S
Abstract excerpt
Protein kinases are thought to mediate their biological effects through their catalytic activity. The large number of pseudokinases in the kinome and an increasing appreciation that they have critical roles in signaling pathways, however, suggest that catalyzing protein phosphorylation may not be the only function of protein kinases. Using the principle of hydrophobic spine assembly, we interpret how kinases are...
Topics
- Allosteric Regulation
- Animals
- Enzyme Activation
- Humans
- Models, Molecular
- Mutation
- Phosphorylation
- Protein Conformation
- Signal Transduction
- raf Kinases