Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.

Pharmacogenetics - 1 Oct 2004

Fukai Hiromi, Ogasawara Yoshino, Migita Ohsuke, Koga Minori, Ichikawa Kunio, Shibasaki Masanao, Arinami Tadao, Noguchi Emiko

Abstract excerpt

OBJECTIVE: Cysteinyl leukotriene receptor 2 (CYSLTR2) is one of the receptors for the cysteinyl leukotrienes (CYSLTs), which cause bronchoconstrictions, vascular hyperpermeability and mucus hypersecretion in asthmatic patients. CYSLTR1 antagonists have been shown to be effective in the treatment of chronic asthma. CYSLTR2 is located approximately 300 kb from D13S153, which is reportedly linked to asthma in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 13

Share to DNA, Complementary

Share to Gene Expression

Share to Linkage Disequilibrium

Share to Tissue Distribution

Source

Identifiers

PMID: 15454733
DOI: 10.1097/00008571-200410000-00006

Genes

CYSLTR2
CYSLTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.PMID 15454733Read ↗

Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.Semantic proximity Read ↗

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma.Semantic proximity Read ↗

Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization.Semantic proximity Read ↗

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.Semantic proximity Read ↗

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesSemantic proximity Read ↗

927T>C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis.Semantic proximity Read ↗

Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trendsSemantic proximity Read ↗

Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes.Semantic proximity Read ↗

Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.Semantic proximity Read ↗

Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene StructureSemantic proximity Read ↗

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.Semantic proximity Read ↗

G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.