Article
G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.
Molecular diagnosis & therapy - 1 Jan 2006
Thompson Miles D, Takasaki Jun, Capra Valérie, Rovati G Enrico, Siminovitch Kathy A, Burnham W McIntyre, Hudson Thomas J, Bossé Yohan, Cole David E C
Abstract excerpt
Genetic variation in specific G-protein coupled receptors (GPCRs) is associated with a spectrum of respiratory disease predispositions and drug response phenotypes. Although certain GPCR gene variants can be disease-causing through the expression of inactive, overactive, or constitutively active receptor proteins, many more GPCR gene variants confer risk for potentially deleterious endophenotypes. Endophenotypes...
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