Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.

Pharmacogenetics - 1 Sept 2004

Pillai Sreekumar G, Cousens Diane J, Barnes Ashley A, Buckley Peter T, Chiano Mathias N, Hosking Louise K, Cameron Lee-Ann, Fling Mary E, Foley James J, Green Andrew, Sarau Henry M, Schmidt Dulcie B, Sprankle Catherine S, Blumenthal Malcolm N, Vestbo Jorgen, Kennedy-Wilson Karen, Wixted William E, Wagner Michael J, Anderson Wayne H, Ignar Diane M

Abstract excerpt

BACKGROUND: Cysteinyl leukotrienes (CYSLTR) are potent biological mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and CYSLTR2. The leukotriene modifying agents currently used to control bronchoconstriction and inflammation in asthmatic patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Cloning, Molecular

Share to Family Health

Share to Leukotrienes

Share to Linkage Disequilibrium

Share to Membrane Proteins

Source

Identifiers

PMID: 15475736
DOI: 10.1097/00008571-200409000-00007

Genes

CYSLTR2
CYSLTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15475736-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.PMID 15475736Read ↗

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesSemantic proximity Read ↗

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.Semantic proximity Read ↗

Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trendsSemantic proximity Read ↗

927T>C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis.Semantic proximity Read ↗

G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.Semantic proximity Read ↗

Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.Semantic proximity Read ↗

Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort.Semantic proximity Read ↗

Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.Semantic proximity Read ↗

A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate.Semantic proximity Read ↗

Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.Semantic proximity Read ↗

Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma.Semantic proximity Read ↗

Cysteinyl leukotriene receptor 1 gene variation and risk of asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.