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Article

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2006

Hao L, Sayers I, Cakebread J A, Barton S J, Beghé B, Holgate S T, Sampson A P, Holloway J W

Abstract excerpt

BACKGROUND: The cysteinyl-leukotriene receptor type 1 (CysLT1) mediates the bronchoconstrictor and pro-inflammatory actions of cysteinyl-leukotrienes (LTC4, LTD4, LTE4) in asthma and is the molecular target of the lukast class of oral anti-leukotriene drugs. We screened the CYSLTR1 gene on chromosome Xq13-21 for coding region polymorphisms, and investigated their associations with allergy and asthma. METHODS:...

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Identifiers

PMID: 16776674
DOI: 10.1111/j.1365-2222.2006.02511.x

Genes

CYSLTR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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