Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle.

Journal of cell science - 15 Oct 2004

Lidonnici Maria Rosa, Rossi Rossella, Paixão Sonia, Mendoza-Maldonado Ramiro, Paolinelli Roberta, Arcangeli Caterina, Giacca Mauro, Biamonti Giuseppe, Montecucco Alessandra

Abstract excerpt

In eukaryotes, initiation of DNA replication requires the activity of the origin recognition complex (ORC). The largest subunit of this complex, Orc1p, has a critical role in this activity. Here we have studied the subnuclear distribution of the overexpressed human Orc1p during the cell cycle. Orc1p is progressively degraded during S-phase according to a spatio-temporal program and it never colocalizes with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterochromatin

Share to Immunoprecipitation

Share to NIH 3T3 Cells

Share to Origin Recognition Complex

Share to Ribonuclease, Pancreatic

Share to S Phase

Source

Identifiers

PMID: 15454574
DOI: 10.1242/jcs.01405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle.PMID 15454574Read ↗

The ORC1 Cycle in Human CellsSemantic proximity Read ↗

ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication originsSemantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.Semantic proximity Read ↗

Two subunits of human ORC are dispensable for DNA replication and proliferationSemantic proximity Read ↗

The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structureSemantic proximity Read ↗

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.Semantic proximity Read ↗

Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeresSemantic proximity Read ↗

Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis.Semantic proximity Read ↗

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlapSemantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.