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Article

The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.

The EMBO journal - 15 Nov 2006

Noguchi Kohji, Vassilev Alex, Ghosh Soma, Yates John L, DePamphilis Melvin L

Abstract excerpt

Selection of initiation sites for DNA replication in eukaryotes is determined by the interaction between the origin recognition complex (ORC) and genomic DNA. In mammalian cells, this interaction appears to be regulated by Orc1, the only ORC subunit that contains a bromo-adjacent homology (BAH) domain. Since BAH domains mediate protein-protein interactions, the human Orc1 BAH domain was mutated, and the mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17066079
DOI: 10.1038/sj.emboj.7601396
PMCID: PMC1636626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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