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Article

The molecular basis of the differential subcellular localization of FYVE domains.

The Journal of biological chemistry - 17 Dec 2004

Blatner Nichole R, Stahelin Robert V, Diraviyam Karthikeyan, Hawkins Phillip T, Hong Wanjin, Murray Diana, Cho Wonhwa

Abstract excerpt

This study systematically analyzed the structural and mechanistic basis of the regulation of subcellular membrane targeting using FYVE domains as a model. FYVE domains, which mediate the recruitment of signaling and membrane-trafficking proteins to phosphatidylinositol 3-phosphate-containing endosomes, exhibit distinct subcellular localization despite minor structural variations within the family. Biophysical...

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PMID: 15452113
DOI: 10.1074/jbc.M408408200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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