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Article

Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.

Molecular biology of the cell - 1 Jul 2003

Lawe Deirdre C, Sitouah Nachida, Hayes Susan, Chawla Anil, Virbasius Joseph V, Tuft Richard, Fogarty Kevin, Lifshitz Lawrence, Lambright David, Corvera Silvia

Abstract excerpt

Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca2+/CaM is required for early endosome fusion in vitro, however, the molecular basis for this requirement is unknown. An additional requirement for endosome fusion is the protein Early Endosome Antigen 1 (EEA1), and its recruitment to the endosome depends on phosphatidylinositol 3-phosphate [PI(3)P] and...

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Source

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Identifiers

PMID: 12857876
DOI: 10.1091/mbc.e02-09-0591
PMCID: PMC165688

Genes

EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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