Article
Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1.
The Journal of biological chemistry - 8 Mar 2002
Lawe Deirdre C, Chawla Anil, Merithew Eric, Dumas John, Carrington Walter, Fogarty Kevin, Lifshitz Lawrence, Tuft Richard, Lambright David, Corvera Silvia
Abstract excerpt
Early endosome antigen 1 (EEA1) is a 170-kDa polypeptide required for endosome fusion in mammalian cells. The COOH terminus of EEA1 contains a FYVE domain that interacts specifically with phosphatidylinositol 3-phosphate (PtdIns-3-P) and a Rab5 GTPase binding region adjacent to the FYVE domain. The dual interaction of EEA1 with both PtdIns-3-P and Rab5 has been hypothesized to provide the specificity required to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.