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Article

Phosphoinositides differentially regulate protrudin localization through the FYVE domain.

The Journal of biological chemistry - 30 Nov 2012

Gil Jung-Eun, Kim Eui, Kim Il-Shin, Ku Bonsu, Park Wei Sun, Oh Byung-Ha, Ryu Sung Ho, Cho Wonhwa, Heo Won Do

Abstract excerpt

Protrudin is a FYVE (Fab 1, YOTB, Vac 1, and EEA1) domain-containing protein involved in transport of neuronal cargoes and implicated in the onset of hereditary spastic paraplegia. Our image-based screening of the lipid binding domain library revealed novel plasma membrane localization of the FYVE domain of protrudin unlike canonical FYVE domains that are localized to early endosomes. The membrane binding study...

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Source

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Identifiers

PMID: 23043110
DOI: 10.1074/jbc.M112.419127
PMCID: PMC3510825

Genes

EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphoinositides differentially regulate protrudin localization through the FYVE domain.PMID 23043110Read ↗

Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic ParaplegiaSemantic proximity Read ↗

The molecular basis of the differential subcellular localization of FYVE domains.Semantic proximity Read ↗

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.Semantic proximity Read ↗

Phosphatidylinositol 3-phosphate recognition by the FYVE domain.Semantic proximity Read ↗

Structural basis for endosomal targeting by FYVE domains.Semantic proximity Read ↗

Protrudin acts at ER-endosome contacts to promote KIF5-mediated endosomal fission and endosome-to-Golgi transportSemantic proximity Read ↗

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.Semantic proximity Read ↗

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