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Article

Membrane insertion of the FYVE domain is modulated by pH.

Proteins - 1 Sept 2009

He Ju, Vora Mohsin, Haney Rachel M, Filonov Grigory S, Musselman Catherine A, Burd Christopher G, Kutateladze Andrei G, Verkhusha Vladislav V, Stahelin Robert V, Kutateladze Tatiana G

Abstract excerpt

The FYVE domain associates with phosphatidylinositol 3-phosphate [PtdIns(3)P] in membranes of early endosomes and penetrates bilayers. Here, we detail principles of membrane anchoring and show that the FYVE domain insertion into PtdIns(3)P-enriched membranes and membrane-mimetics is substantially...

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Source

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Identifiers

PMID: 19296456
DOI: 10.1002/prot.22392
PMCID: PMC2909462

Genes

EEA1
RUFY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19296456-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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