Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatidylinositol 3-phosphate recognition by the FYVE domain.

Molecular cell - 1 Jun 1999

Kutateladze T G, Ogburn K D, Watson W T, de Beer T, Emr S D, Burd C G, Overduin M

Abstract excerpt

Recognition of phosphatidylinositol 3-phosphate (Ptdlns(3)P) is crucial for a broad range of cellular signaling and membrane trafficking events regulated by phosphoinositide (PI) 3-kinases. PtdIns(3)P binding by the FYVE domain of human early endosome autoantigen 1 (EEA1), a protein implicated in endosome fusion, involves two beta hairpins and an alpha helix. Specific amino acids, including those of the FYVE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liposomes
Share to Nuclear Magnetic Resonance, Biomolecular
Share to Phosphatidylinositol Phosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositols

Share to Solubility

Share to Vesicular Transport Proteins

Share to Zinc Fingers

Source

Identifiers

PMID: 10394369
DOI: 10.1016/s1097-2765(01)80013-7

Genes

EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatidylinositol 3-phosphate recognition by the FYVE domain.PMID 10394369Read ↗

Structural basis for endosomal targeting by FYVE domains.Semantic proximity Read ↗

The molecular basis of the differential subcellular localization of FYVE domains.Semantic proximity Read ↗

Membrane insertion of the FYVE domain is modulated by pH.Semantic proximity Read ↗

Phosphoinositides differentially regulate protrudin localization through the FYVE domain.Semantic proximity Read ↗

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.Semantic proximity Read ↗

Traffic to the malaria parasite food vacuole: a novel pathway involving a phosphatidylinositol 3-phosphate-binding protein.Semantic proximity Read ↗

Molecular basis for plasma membrane recruitment of PI4KA by EFR3Semantic proximity Read ↗

Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif.Semantic proximity Read ↗

Molecular basis for plasma membrane recruitment of PI4KA by EFR3.Semantic proximity Read ↗

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusionSemantic proximity Read ↗

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.Semantic proximity Read ↗

Supertertiary structure of the MAGUK core from PSD-95.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.