Article
Microarray-based AMASE as a novel approach for mutation detection.
Mutation research - 4 Oct 2004
Käller Max, Ahmadian Afshin, Lundeberg Joakim
Abstract excerpt
Alterations in the p53 tumor suppressor gene are important events in many cases of human cancers. We have developed a novel microarray based approach for re-sequencing and mutation detection of the p53 gene. The method facilitates rapid and simple scanning of the target gene sequence and could be expanded to include other candidate cancer genes. The methodology employs the previously described apyrase-mediated...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Humans
- Oligonucleotide Array Sequence Analysis
- Oligonucleotides