Article
p53 Mutation analysis in breast tumors by a DNA microarray method.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2006
Tennis Meredith, Krishnan Shiva, Bonner Matthew, Ambrosone Christine B, Vena John E, Moysich Kirsten, Swede Helen, McCann Susan, Hall Per, Shields Peter G, Freudenheim Jo L
Abstract excerpt
The p53 gene acts as a regulator of cell growth and DNA repair in normal cells; inactivation of the gene seems to lead to cancer. It is the most commonly mutated gene in human cancers, and a high-throughput sequencing method is needed for cancer etiology studies using large sample sets. In our population-based case-control study of breast cancer, the p53 gene was amplified by PCR for 392 subjects from seven...
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