Article
Highly selective isolation of unknown mutations in diverse DNA fragments: toward new multiplex screening in cancer.
Cancer research - 15 Jul 2000
Chakrabarti S, Price B D, Tetradis S, Fox E A, Zhang Y, Maulik G, Makrigiorgos G M
Abstract excerpt
Cancer research would greatly benefit from technologies that allow simultaneous screening of several unknown gene mutations. Lack of such methods currently hampers the large-scale detection of genetic alterations in complex DNA samples. We present a novel mismatch-capture methodology for the highly efficient isolation and amplification of mutation-containing DNA from diverse nucleic acid fragments of unknown...
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