Article
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients.
Human genetics - 1 Nov 2004
Kim I-J, Ku J-L, Kang H C, Park J-H, Yoon K-A, Shin Y, Park H-W, Jang S G, Lim S-K, Han S Y, Shin Y-K, Lee M R, Jeong S-Y, Shin H-R, Lee J S, Kim W-H, Park J-G
Abstract excerpt
MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in patients with multiple adenomas or familial adenomatous polyposis (FAP). A total of 20 APC-negative Korean FAP patients were analyzed for OGG1, MYH and MTH1 germline mutations. A total of 19 hereditary nonpolyposis colorectal cancer (HNPCC), 86 suspected HNPCC, and 246 sporadic colorectal...
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