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Article

Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer.

Oxidative medicine and cellular longevity - 1 Jan 2014

Shinmura Kazuya, Goto Masanori, Tao Hong, Kato Hisami, Suzuki Rie, Nakamura Satoki, Matsuda Tomonari, Yin Guang, Morita Makiko, Kono Suminori, Sugimura Haruhiko

Abstract excerpt

PURPOSE: The biallelic inactivation of the 8-hydroxyguanine repair gene MUTYH leads to MUTYH-associated polyposis (MAP), which is characterized by colorectal multiple polyps and carcinoma(s). However, only limited information regarding MAP in the Japanese population is presently available. Since early-onset colorectal cancer (CRC) is a characteristic of MAP and might be caused by the inactivation of another...

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Source

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Identifiers

PMID: 24799981
DOI: 10.1155/2014/617351
PMCID: PMC3988950

Genes

MUTYH
OGG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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