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Article

Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

Journal of the National Cancer Institute - 21 Aug 2013

Smith Christopher G, West Hannah, Harris Rebecca, Idziaszczyk Shelley, Maughan Timothy S, Kaplan Richard, Richman Susan, Quirke Philip, Seymour Matthew, Moskvina Valentina, Steinke Verena, Propping Peter, Hes Frederik J, Wijnen Juul, Cheadle Jeremy P

Abstract excerpt

Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker association analyses were assessed under an allelic model with Bonferroni correction for multiple testing. All statistical tests...

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Identifiers

PMID: 23852950
DOI: 10.1093/jnci/djt183

Genes

OGG1
MUTYH

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