Article
Analysis of the oxidative damage repair genes NUDT1, OGG1, and MUTYH in patients from mismatch repair proficient HNPCC families (MSS-HNPCC).
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2011
Garre Pilar, Briceño Verónica, Xicola Rosa M, Doyle Brian J, de la Hoya Miguel, Sanz Julián, Llovet Patricia, Pescador Paula, Puente Javier, Díaz-Rubio Eduardo, Llor Xavier, Caldés Trinidad
Abstract excerpt
PURPOSE: Several studies have described molecular differences between microsatellite stable hereditary nonpolyposis colorectal cancer (MSS-HNPCC) and microsatellite unstable Lynch syndrome tumors (MSI-HNPCC). These differences highlight the possibility that other instability forms could explain cancer susceptibility in this group of families. The base excision repair (BER) pathway is the major DNA repair pathway...
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