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Article

Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response.

The international journal of neuropsychopharmacology - 1 Dec 2004

Lemonde Sylvie, Du Lisheng, Bakish David, Hrdina Pavel, Albert Paul R

Abstract excerpt

Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (e.g. fluoxetine, nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which may contribute to their clinical efficacy. The 5-HT1A receptor gene is repressed by NUDR/DEAF-1 in raphe cells at the C-, but not at the G-allele of the C(-1019)G polymorphism that is associated with major depression and suicide....

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Identifiers

PMID: 15447813
DOI: 10.1017/S1461145704004699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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