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Article

Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Sept 2003

Lemonde Sylvie, Turecki Gustavo, Bakish David, Du Lisheng, Hrdina Pavel D, Bown Christopher D, Sequeira Adolfo, Kushwaha Neena, Morris Stephen J, Basak Ajoy, Ou Xiao-Ming, Albert Paul R

Abstract excerpt

Inhibition of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A autoreceptors, which may be increased in depressed patients. We report an association of the C(-1019)G 5-HT1A promoter polymorphism with major depression and suicide in separate cohorts. In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele...

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Identifiers

PMID: 14507979
PMCID: PMC6740417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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