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Article

Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2003

Zill Peter, Baghai Thomas C, Engel Rolf, Zwanzger Peter, Schüle Cornelius, Minov Christo, Behrens Stefanie, Bottlender Ronald, Jäger Markus, Rupprecht Rainer, Möller Hans-Jürgen, Ackenheil Manfred, Bondy Brigitta

Abstract excerpt

Noradrenergic dysfunction has been implicated in the development of affective disorders. beta-adrenergic receptors (betaARs) mediate the response to norephinephrine, are coupled to the cAMP signaling cascade, supposed to be altered in their density and/or sensitivity in depression, and down regulated in several brain regions after long term treatment with different but not all antidepressants. A recently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12815745
DOI: 10.1002/ajmg.b.20017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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