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Article

SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.

Psychiatric genetics - 1 Dec 2009

Villafuerte Sandra M, Vallabhaneni Kamala, Sliwerska Elzbieta, McMahon Francis J, Young Elizabeth A, Burmeister Margit

Abstract excerpt

OBJECTIVES: Desensitization of serotonin 1A (HTR1A) and 1B (HTR1B) autoreceptors has been proposed to be involved in the delayed onset of response to selective serotonin reuptake inhibitors (SSRIs). Variations in gene expression in these genes may thus affect SSRI response. METHODS: Here, we test this hypothesis in two samples from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D), and show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptor Mechanisms and Signaling

Share to Receptor, Serotonin, 5-HT1A

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Identifiers

PMID: 19829169
DOI: 10.1097/YPG.0b013e32832a506e
PMCID: PMC2783179

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