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Article

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness.

Molecular diagnosis & therapy - 1 Jan 2007

Levin Gary M, Bowles Toya M, Ehret Megan J, Langaee Taimour, Tan Jennifer Y, Johnson Julie A, Millard William J

Abstract excerpt

BACKGROUND: Depression is thought to involve, in part, dysregulation of serotonergic neurotransmission. In depressed individuals, the number of serotonin receptors, including the 5-hydroxytryptamine (serotonin)-1A (5-HT(1A)) autoreceptors, are increased. Clinical improvement with selective serotonin reuptake inhibitors (SSRIs) is not usually observed until several weeks after treatment initiation. This delay may...

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PMID: 17570737
DOI: 10.1007/BF03256237

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