Article
Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder.
The international journal of neuropsychopharmacology - 1 Mar 2009
Szewczyk Bernadeta, Albert Paul R, Burns Ariel M, Czesak Margaret, Overholser James C, Jurjus George J, Meltzer Herbert Y, Konick Lisa C, Dieter Lesa, Herbst Nicole, May Warren, Rajkowska Grazyna, Stockmeier Craig A, Austin Mark C
Abstract excerpt
A variety of studies have documented alterations in 5-HT1A receptor binding sites in the brain of subjects with major depressive disorder (MDD). The recently identified transcription factor, nuclear deformed epidermal autoregulatory factor (NUDR/Deaf-1) has been shown to function as a transcriptional modulator of the human 5-HT1A receptor gene. The present study was undertaken to document the regional and...
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