Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice

10 Jan 2012

Abstract excerpt

Altered regulation of the serotonin-1A (5-HT1A) receptor gene is implicated in major depression and mood disorders. The functional human 5-HT1A C(-1019)G promoter polymorphism (rs6295), which prevents the binding of Deaf-1/NUDR leading to dysregulation of the receptor, has been associated with major depression. In cell models Deaf-1 displays dual activity, repressing 5-HT1A autoreceptor expression in serotonergic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypothalamic control of reproductive hormones
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor Mechanisms and Signaling

Source

Identifiers

PMID: 22232550
DOI: 10.1074/jbc.m111.293027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out MicePMID 22232550Read ↗

Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.Semantic proximity Read ↗

Functional interrogation of a depression-related serotonergic SNP, rs6295, using a humanized mouse modelSemantic proximity Read ↗

Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide.Semantic proximity Read ↗

Transcriptional regulation at a HTR1A polymorphism associated with mental illness.Semantic proximity Read ↗

Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.Semantic proximity Read ↗

5-HT1A receptors, gene repression, and depression: guilt by association.Semantic proximity Read ↗

Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder.Semantic proximity Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.Semantic proximity Read ↗

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Serotonin receptors in depression: from A to BSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.