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Article

Electrophoretic analysis of low and high activity forms of catechol-O-methyltransferase in human erythrocytes.

Life sciences - 1 Jan 1992

Grossman M H, Szumlanski C, Littrell J B, Weinstein R, Weinshilboum R M

Abstract excerpt

Analysis of the catechol-O-methyltransferase (COMT) enzyme in human RBC lysates from 15 samples exhibiting inherited variations in level of activity and thermal stability was performed. Electrophoretic blotting and immune fixation was carried out following sodium dodecyl sulfate polyacrylamide gel electrophoresis or isoelectric focusing of lysate protein. These techniques did not reveal a major structural...

Topics

Catechol O-Methyltransferase
Electrophoresis, Polyacrylamide Gel
Enzyme Stability
Erythrocytes
Humans
Immunoblotting
Isoelectric Point
Molecular Weight
Phenotype
Polymorphism, Genetic
Random Allocation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Source

Identifiers

PMID: 1542252
DOI: 10.1016/0024-3205(92)90386-4

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1542252-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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