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Article

Catechol-O-methyltransferase low activity genotype (COMTLL) is associated with low levels of COMT protein in human hepatocytes.

Cancer letters - 28 Oct 2004

Doyle Anne E Sullivan, Goodman Julie E, Silber Paul M, Yager James D

Abstract excerpt

A single nucleotide polymorphism in the COMT (catechol-O-methyltransferase) gene that alters the amino acid sequence at codon 108 of S-COMT from val to met (val108met polymorphism) has been associated with a number of diseases and neuropsychiatric disorders. Several studies have shown that the met108 allele (COMTL) is associated with three to four-fold lower levels of COMT activity, compared to the val108 allele...

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Source

Identifiers

PMID: 15363545
DOI: 10.1016/j.canlet.2004.06.033

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Catechol-O-methyltransferase low activity genotype (COMTLL) is associated with low levels of COMT protein in human hepatocytes.PMID 15363545Read ↗

Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies.Semantic proximity Read ↗

Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells.Semantic proximity Read ↗

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes.Semantic proximity Read ↗

The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo.Semantic proximity Read ↗

Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.Semantic proximity Read ↗

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.Semantic proximity Read ↗

The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.Semantic proximity Read ↗

Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population.Semantic proximity Read ↗

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.Semantic proximity Read ↗

Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.Semantic proximity Read ↗

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

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