Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.

Article

Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.

The Journal of pharmacology and experimental therapeutics - 1 Jul 1994

McLeod H L, Fang L, Luo X, Scott E P, Evans W E

Abstract excerpt

Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Human COMT activity is inherited as an autosomal co-dominant trait; approximately 25% of white individuals have low activity consistent with homozygosity for a low...

Topics

Adolescent
Adult
Aged
Black People
Catechol O-Methyltransferase
Erythrocytes
Ethnicity
Female
Humans
Male
Middle Aged
Phenotype
United States
White People
Black or African American

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