Article
Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.
The Journal of pharmacology and experimental therapeutics - 1 Jul 1994
McLeod H L, Fang L, Luo X, Scott E P, Evans W E
Abstract excerpt
Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Human COMT activity is inherited as an autosomal co-dominant trait; approximately 25% of white individuals have low activity consistent with homozygosity for a low activity allele, about 50% have intermediate activity (i.e., heterozygous genotype) and 25% have high activity. COMT...
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