Article
Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.
Pharmacogenetics - 1 Jun 1998
McLeod H L, Syvänen A C, Githang'a J, Indalo A, Ismail D, Dewar K, Ulmanen I, Sludden J
Abstract excerpt
Catechol O-methyltransferase (COMT) inactivates neurotransmitters, hormones and drugs such as levodopa. COMT activity is inherited in an autosomal recessive manner and individuals with low activity have thermolabile COMT protein. A low activity allele has been demonstrated at codon 108/158 of the...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Black People
- Catechol O-Methyltransferase
- Codon
- Erythrocytes
- Female
- Gene Frequency
- Genotype
- Humans
- India
- Kenya
- Male
- Middle Aged
- Pakistan