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Article

Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells.

Biochimica et biophysica acta - 1 Jan 2008

Doyle Anne E, Yager James D

Abstract excerpt

A single nucleotide polymorphism in the human COMT (catechol-O-methyltransferase) gene has been associated with increased risk for breast cancer and several CNS diseases and disorders. The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L,...

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Source

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Identifiers

PMID: 17980711
DOI: 10.1016/j.bbagen.2007.10.002
PMCID: PMC2198850

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells.PMID 17980711Read ↗

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An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

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