Article
Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability.
Archives of biochemistry and biophysics - 15 Oct 1997
David C L, Szumlanski C L, DeVry C G, Park-Hah J O, Clarke S, Weinshilboum R M, Aswad D W
Abstract excerpt
Protein L-isoaspartyl methyltransferase (PIMT) is believed to play an important role in the disposition of age-damaged proteins by catalyzing the repair of abnormal isoaspartyl linkages resulting from the spontaneous deamidation of asparaginyl residues or isomerization of aspartyl residues. As a step toward testing the hypothesis that human disease- or age-related pathology might be associated with a deficiency...
Topics
- Aging
- Alleles
- Enzyme Stability
- Erythrocytes
- Heterozygote
- Homozygote
- Hot Temperature
- Humans
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Protein D-Aspartate-L-Isoaspartate Methyltransferase
- Protein Methyltransferases