Article
Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions.
Molecular carcinogenesis - 1 Dec 1995
Suzui M, Yoshimi N, Tanaka T, Mori H
Abstract excerpt
The alkylating agent 4-nitroquinoline 1-oxide (4-NQO) is a powerful carcinogen and induces squamous cell hyperplasia, squamous cell dysplasia, papilloma, and squamous cell carcinoma (SCC) in rat oral epithelia. Oral cancers induced by a single application of 4-NQO develop through a multistage pro...
Topics
- 4-Nitroquinoline-1-oxide
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- Exons
- Gene Deletion
- Genes, p53
- Genes, ras
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Papilloma
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precancerous Conditions
- Rats
- Rats, Inbred F344