Article
N-ras mutation in ultraviolet radiation-induced murine skin cancers.
Cancer research - 15 Jul 1992
Pierceall W E, Kripke M L, Ananthaswamy H N
Abstract excerpt
UV radiation is a potent DNA-damaging agent and a known inducer of skin cancer in experimental animals. To elucidate the role of oncogenes in UV carcinogenesis, we analyzed UV-induced murine skin tumors for mutations in codon 12, 13, or 61 of Ha-ras, Ki-ras, and N-ras oncogenes by amplification of genomic tumor DNAs by the polymerase chain reaction followed by dot-blot hybridization to synthetic oligonucleotide...
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