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Article

N-ras mutation in ultraviolet radiation-induced murine skin cancers.

Cancer research - 15 Jul 1992

Pierceall W E, Kripke M L, Ananthaswamy H N

Abstract excerpt

UV radiation is a potent DNA-damaging agent and a known inducer of skin cancer in experimental animals. To elucidate the role of oncogenes in UV carcinogenesis, we analyzed UV-induced murine skin tumors for mutations in codon 12, 13, or 61 of Ha-ras, Ki-ras, and N-ras oncogenes by amplification of genomic tumor DNAs by the polymerase chain reaction followed by dot-blot hybridization to synthetic oligonucleotide...

Topics

Animals
Base Sequence
Codon
DNA, Neoplasm
Genes, ras
Immunoblotting
Mice
Mice, Inbred C3H
Molecular Sequence Data
Mutation
Neoplasms, Radiation-Induced
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin Neoplasms

Source

Identifiers

PMID: 1617670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1617670-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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