Article
p53 mutations in MeIQ-induced mouse forestomach tumors.
Nihon Ika Daigaku zasshi - 1 Feb 1997
Makino H, Ushijima T, Onda M, Nagao M
Abstract excerpt
A method was established for detecting mutations in the mouse p53 gene by cDNA-PCR-SSCP, using four cell lines which were derived from forestomach tumors induced in CDF, mice by 2-amino-3,4-dimethylimidazo [4,5-f]quinoline (MeIQ). All the cell lines were demonstrated to have mutations in exons 4,...
Topics
- Animals
- Carcinoma, Squamous Cell
- Genes, p53
- Mice
- Mice, Inbred Strains
- Mutagens
- Mutation
- Papilloma
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Quinolines
- Stomach Neoplasms
- Tumor Cells, Cultured