Article
p53 mutations in MeIQ-induced mouse forestomach tumors.
Nihon Ika Daigaku zasshi - 1 Feb 1997
Makino H, Ushijima T, Onda M, Nagao M
Abstract excerpt
A method was established for detecting mutations in the mouse p53 gene by cDNA-PCR-SSCP, using four cell lines which were derived from forestomach tumors induced in CDF, mice by 2-amino-3,4-dimethylimidazo [4,5-f]quinoline (MeIQ). All the cell lines were demonstrated to have mutations in exons 4, 5, 7 and 10, respectively, and the method was confirmed to be efficient and reliable. It was therefore used to analyse...
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