Article
Activated oncogenes and putative tumor suppressor genes involved in human breast cancers.
Cancer treatment and research - 1 Jan 1992
Tripathy D, Benz C C
Abstract excerpt
Cytogeneticists first proposed that the karyotypic abnormalities identified on chromosomes 1, 3, 6, 11, 13, 16, 17, and 18 supported a genetic basis for breast cancer. Such abnormal banding patterns, however, may represent either loss-of-function or gain-of-function molecular events. RFLP analyses have since confirmed that 20-60% of primary and spontaneous human breast tumors exhibit allelic losses on these same...
Topics
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 3
- Female
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement
- Genes, Tumor Suppressor
- Genes, myc