Increased power for case-control studies of single nucleotide polymorphisms through incorporation of family history and genetic constraints.

Abstract excerpt

Association studies assessing the relationship between a common polymorphism and disease generally compare allele frequencies in cases and controls. In such studies, a limited amount of information is often available about disease incidence in relatives. We hypothesised that more power could be obtained by incorporating the constraints imposed by the properties of a genetic polymorphism, and that power could be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Case-Control Studies