Article
Genetic variability of platelet glycoprotein Ibalpha gene.
American journal of hematology - 1 Oct 2004
Ozelo Margareth C, Costa Devanira S P, Siqueira Lucia H, Machado Tania M F, Castro Vagner, Gonçalves Marilda S, Menezes Raimundo C, Soares Manoel, Annichino-Bizzacchi Joyce M, Costa Fernando F, Arruda Valder R
Abstract excerpt
Platelet membrane glycoprotein (GP) Ibalpha is a critical component of platelet adhesion complex to subendothelium structures following tissue injury or pathological surfaces, such as atherosclerotic plaques. Polymorphisms of the GPIbalpha gene have been associated with a high risk for occlusive vascular disease, and its distribution varies considerably among distinct populations. These polymorphisms comprise the...
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