Article
Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease.
Blood - 15 Oct 1998
Gonzalez-Conejero R, Lozano M L, Rivera J, Corral J, Iniesta J A, Moraleda J M, Vicente V
Abstract excerpt
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIbalpha. The relevance of these polymorphi...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, Human Platelet
- Arterial Occlusive Diseases
- Binding Sites
- Case-Control Studies
- Cerebrovascular Disorders
- Coronary Disease
- Female
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Minisatellite Repeats
- Platelet Glycoprotein GPIb-IX Complex