Article
Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease.
Blood - 15 Oct 1998
Gonzalez-Conejero R, Lozano M L, Rivera J, Corral J, Iniesta J A, Moraleda J M, Vicente V
Abstract excerpt
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIbalpha. The relevance of these polymorphisms to thrombotic disease was investigated by genotypic identification in three case-control studies: 104 case patients...
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