Article
The Kozak sequence polymorphism of platelet glycoprotein Ibalpha and risk of nonfatal myocardial infarction and nonfatal stroke in young women.
Blood - 15 Feb 2001
Frank M B, Reiner A P, Schwartz S M, Kumar P N, Pearce R M, Arbogast P G, Longstreth W T, Rosendaal F R, Psaty B M, Siscovick D S
Abstract excerpt
Several platelet membrane glycoprotein polymorphisms have been identified as potential risk factors for cardiovascular disease. Recently a nucleotide -5T/C dimorphism in the translation initiation site (Kozak sequence) of the platelet glycoprotein Ibalpha (GPIbalpha) gene was associated with increased platelet surface levels of the GPIb-IX-V receptor complex. The role of this GPIbalpha Kozak sequence polymorphism...
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