Article
Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) dimorphisms.
Thrombosis and haemostasis - 1 Sept 1998
Reiner A P, Aramaki K M, Teramura G, Gaur L
Abstract excerpt
Glycoprotein Ia (alpha2 integrin) is a subunit of the heterodimeric membrane complex (GPIa/IIa) that mediates platelet adhesion to collagen. Several nucleotide sequence variations of GPIa have been described. A nucleotide 1648 G/A dimorphism that leads to a Glu/Lys substitution at amino acid 505 is responsible for the human platelet antigen system, HPA-5. Recently, two other linked GPIa nucleotide dimorphisms...
Topics
- Alleles
- Amino Acid Sequence
- Amino Acid Substitution
- Antigens, CD
- Base Sequence
- Blood Platelets
- Gene Frequency
- Glutamine
- Humans
- Integrin alpha2
- Lysine